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Select Publications & Patents

Below are some academic publications and patents from the team. As drug discovery and development is our major focus, much of our work first contributes to patents and regulatory applications for novel therapeutics, with academic publications following later. So, in addition to the below, take a look at our Research section to learn more about our current research.

Scholarly Publications
 

2023

  • Tan O, Bowen MT. (2023). The vasopressin V1A receptor and aggression: Challenges and potential novel treatments. In, Anger, Aggression and Violence: Causes, Pathology and Treatments. Springer-Nature.

 
2022

  • Raymond JS, Everett NA, Gururajan A, Bowen MT. (Accepted). The influence of intraperitoneal and intranasal oxytocin on sleep-wake behaviour and neurophysiology in rats. Sleep.

  • Scicluna RL, Wilson BB, Thelaus SH, Arnold JC, McGregor IS, Bowen MT. (2022). Cannabidiol reduced the severity of gastrointestinal symptoms of opioid withdrawal in male and female mice. Cannabis and Cannabinoid Research.

  • Kevin RC, Cairns EA, Boyd R, Arnold JC, Bowen MT, McGregor IS, Banister SD. (2022). Off-Target Pharmacological Profiling of Synthetic Cannabinoid Receptor Agonists including AMB-FUBINACA, CUMYL-PINACA, PB-22, and XLR-11. Frontiers in Psychiatry.

  • Milligan CJ, Anderson LL, Bowen MT, Banister SD, McGregor IS, Arnold JC, Petrou S. (2022). A nutraceutical product, extracted from Cannabis sativa, modulates voltage-gated sodium channel function. Journal of Cannabis Research.

  • Bowen MT, George O, Muskiewicz DE, Hall FS. (2022). Factors contributing to the escalation of alcohol consumption. Neuroscience & Biobehavioral Reviews.

  • Rehn S, Raymond JS, Boakes R, Bowen MT. (2022). Sucrose intake by rats affected by both intraperitoneal oxytocin administration and time of day. Psychopharmacology.

 

2021

  • Raymond JS, Rehn S, Hoyos CM, Bowen MT. (2021). The influence of oxytocin-based interventions on sleep-wake and sleep-related behaviour and neurobiology: a systematic review of preclinical and clinical studies. Neuroscience & Biobehavioral Reviews.

  • Smith AS, Jurek B, Grinevich V, Bowen MT. (2021). The oxytocin system in fear, stress, anguish, and pain. Frontiers in Endocrinology.

  • Anderson LL, Heblinski M… Bowen MT… Kearney JA, Arnold JC. (2021). Cannabigerolic acid, a major biosynthetic precursor molecule in cannabis, exhibits divergent effects on seizures in mouse models of epilepsy. British Journal of Pharmacology

  • Martin LJ, Cairns EA… Bowen MT, Anderson LL. (2021). Cannabichromene and Δ9-

  • Tetrahydrocannabinolic Acid Identified as Lactate Dehydrogenase-A Inhibitors by in Silico and in Vitro Screening. Journal of Natural Products.

  • Martin LJ, Banister SD, Bowen MT. (2021). Understanding the complex pharmacology of cannabidiol: mounting evidence suggests a common binding site with cholesterol. Pharmacological Research.

 
2020

  • Martin L & Bowen MT. (2020). Comparing fingerprints for ligand-based virtual screening: a fast, scalable approach for unbiased evaluation. Journal of Chemical Information and Modeling

  • Absalom N, Liao V,… Bowen MT… Dale R, Chebib M. (2020). Gain-of-function GABRB3 variants identified in vigabatrin-hypersensitive epileptic encephalopathies. Brain Communications

  • Tan O, Martin LJ, Bowen MT. (2020). Divergent pathways mediate 5-HT1A receptor agonist effects on close social interaction, grooming and aggressive behaviour in mice: Exploring the involvement of the oxytocin and vasopressin systems. Journal of Psychopharmacology

 
2019

  • Raymond JS, Wilson BB, Tan O, Gururajan A, & Bowen MT. (2019). Acute alcohol exposure dosedependently alleviates social avoidance in adolescent mice and inhibits social investigation in adult mice. Psychopharmacology. doi:10.1007/s00213-019-05335-8

  • Bowen MT. (2019). Does peripherally administered oxytocin enter the brain? Compelling new evidence in a long-running debate. Pharmacological Research.

  • Tan O, Musullulu H, Raymond JS, Wilson B, Langguth M, Bowen MT. (2019). Oxytocin and vasopressin inhibit hyper-aggressive behaviour in socially isolated mice. Neuropharmacology

  • Absalom NL,… Bowen MT, Chebib M. (2019). Functional genomics of epilepsy-associated mutations in the GABAA receptor subunits reveal that one mutation impairs function and two are catastrophic. Journal of Biological Chemistry.

 
2011 - 2018

  • Bowen MT, Neumann ID. (2018). The multidimensional therapeutic potential of targeting the brain oxytocin system for the treatment of substance use disorders. Current Topics in Behavioral Neurosciences. 35, 269-287.

  • Meiser B,… Bowen MT, Mills L, Kirk J (2018). Psychological outcomes and surgical decisions after genetic testing in women newly diagnosed with breast cancer with and without a family history. European Journal of Human Genetics.

  • Bowen MT, Neumann ID. (2017). Rebalancing the addicted brain: Oxytocin interference with the neural substrates of addiction (Feature Review). Trends in Neurosciences, 40 (12), 691-708

  • Bowen MT*, Peters ST*, McGregor IS, Neumann ID. (2017). Oxytocin inhibits ethanol consumption and ethanol-induced dopamine release in the nucleus accumbens. Addiction Biology, 22 (3), 702-711 (56 citations) *Shared lead author

  • Suraev AS, Todd L, Bowen MT, Allsop D, McGregor IS, Ireland C, Lintzeris N. (2017). An Australian nationwide survey on medicinal cannabis use for epilepsy: History of antiepileptic drug treatment predicts medicinal cannabis use. Epilepsy and Behavior, 70, 334-340.

  • Quinn VF,… Bowen MT, Mitchell G. (2017). Streamlined genetic education is effective in preparing women newly diagnosed with breast cancer for decision-making about treatment-focused genetic testing: A randomised controlled non-inferiority trial. Genetics in Medicine. 19(4). 448-456

  • Bowen MT, Liu J, Buisman-Pijlman FTA. (2016). Oxytocin: providing new avenues for treating and understanding problematic drug use. In V. Preedy (Ed.), The Neuropathology of Drug Addictions and Substance Misuse. Academic Press: London, 82-92

  • Bowen MT, Peters ST, Absalom N, Chebib M, Neumann ID, McGregor IS. (2015). Oxytocin prevents ethanol actions at δ subunit-containing GABAA receptors and attenuates ethanol-induced motor impairment in rats. Proceedings of the National Academy of Sciences, 112(10), 3104-3109.

  • Bowen MT. (2014). Miscellaneous Hormones. In S. Ray (Ed.), Side Effects of Drugs Annual 36. Elsevier:Netherlands, 659-673.

  • Bowen MT, McGregor IS. (2014). Oxytocin and vasopressin modulate the social response to threat: a preclinical study. The International Journal of Neuropsychopharmacology, 17:1621-33.

  • Bowen MT, Hari Dass SA, Booth J, Suraev A, Vyas A, McGregor IS. (2014). Active coping toward predatory stress is associated with lower corticosterone and progesterone plasma levels and decreased methylation in the medial amygdala vasopressin system. Hormones and Behavior 66:561-566.

  • Suraev AS, Bowen MT, Ali SO, Hicks C, Ramos L, McGregor IS. (2014). Adolescent exposure to oxytocin, but not the selective oxytocin receptor agonist TGOT, increases social behavior and plasma oxytocin in adulthood. Hormones and Behavior 65:488-496.

  • McGregor IS, Bowen MT. (2013). Oxytocin and addiction: recent preclinical advances and future clinical potential. In E. Choleris, D. Pfaff, & M. Kavaliers (Eds.), Oxytocin, Vasopressin and Related Peptides in the Regulation of Behavior. Cambridge, UK: Cambridge University Press, 270-287.

  • Bowen MT, Kevin RC, May M, Staples LG, Hunt GE, McGregor IS. (2013). Defensive aggregation (huddling) in Rattus norvegicus toward predator odor: Individual differences, social buffering effects and neural correlates. PLoS One: 8:e68483.

  • Motbey CP,… Bowen MT, Cornish JL, McGregor IS. (2013). High levels of intravenous mephedrone selfadministration in rats: Neural consequences and comparison with methamphetamine. Journal of Psychopharmacology 27:823-836.

  • Bowen MT, Keats K, Kendig MD, Cakic V, Callaghan PD, McGregor IS. (2012). Aggregation in quads but not pairs of rats exposed to cat odor or bright light. Behavioural Processes 90: 331-336.

  • May M, Bowen MT, McGregor IS, Timberlake W. (2012). Rubbings deposited by cats elicit defensive behavior in rats. Physiology and Behavior 107:711-18.

  • McGregor IS, Bowen MT. (2012). Breaking the loop: Oxytocin as a potential treatment for drug addiction. Hormones and Behavior 61: 331-339.

  • Bowen MT, Carson DS, Spiro A, Arnold JC, McGregor IS. (2011). Adolescent Oxytocin Exposure Causes Persistent Reductions in Anxiety and Alcohol Consumption and Enhances Sociability in Rats. PLoS ONE 6(11): e27237.

  • Motbey CP, Hunt GE, Bowen MT, Artiss S, McGregor IS. (2011). Mephedrone (4-Methylmethcathinone, "Meow"): Acute Behavioural Effects and Distribution of Fos Expression in Adolescent Rats. Addiction Biology. 2(17):409-22.

  • Kendig MD, Bowen MT, Kemp AH, McGregor IS. (2011). Predatory threat induces huddling in adolescent rats and residual changes in early adulthood suggestive of increased resilience. Behavioural Brain Research225: 405-14.

Preprints
 

  • Raymond JS, Everett NA, Gururajan A, Bowen MT. (2022). Quiet wakefulness: The influence of intraperitoneal and intranasal oxytocin on sleep-wake behaviour and neurophysiology in rats. BioRxiv

  • Martin L & Bowen MT. (2019). The missing label problem: addressing false assumptions improves ligand based virtual screening. ChemRxiv

Patents

Patent family: Therapeutic compounds and compositions for treating social disorders and substance use disorders. Bowen MT (co-lead inventor), McGregor IS, Kassiou M, Hicks C, Jorgensen W.

  • European Patent Convention Patent 3328864 (Granted 2022)

  • Japan Patent 7089825 (Granted 2022)

  • Hong Kong Patent HK1252813 (Granted 2022)

  • Israel Patent 256684 (Granted 2022)

  • Mexico Patent 389545 (Granted 2022)

  • USA Patent 11033555 (Granted 2021).

  • Australian Patent 2016289271 (Granted 2021).

  • Chinese Patent 201680040337.2 (Granted 2021).

  • Russian Federation Patent 2715384 (Granted 2020, abandoned 2022).

  • Brazilian Patent Application BR1120180000590 (Published 2018)

  • Canadian Patent Application 2991236 (Published 2018)

  • Indian Patent Application 201717046363 (Published 2018)

  • Republic of Korea Patent Application 10-2018-7003161 (Published 2018)

  • South African Patent Application 2018/00530 (Published 2018)

  • New Zealand Patent 738672 (Granted 2023)

  • Austrian Patent AT3328864 (Granted 2022)

  • Belgium Patent BE3328864 (Granted 2022)

  • Czech Republic Patent CZ3328864 (Granted 2022)

  • Denmark Patent DK3328864 (Granted 2022)

  • Finish Patent FI3328864 (Granted 2022)

  • French Patent FR3328864 (Granted 2022)

  • German Patent DE3328864 (Granted 2022)

  • Irish Patent IE3328864 (Granted 2022)

  • Netherlands Patent NL3328864 (Granted 2022)

  • Polish Patent PL3328864 (Granted 2023)

  • Portugal Patent PT3328864 (Granted 2022)

  • Slovenia Patent SI3328864 (Granted 2023)

  • Spain Patent ES3328864 (Granted 2023)

  • Switzerland & Lichtenstein Patent CHL3328864 (Granted 2022)

  • Swedish Patent SE3328864 (Granted 2022)

  • Turkish Patent TR3328864 (Granted 2022)

  • United Kingdom Patent GB3328864 (Granted 2022)

  • Hungarian Patent HU3328864 (Granted 2023)

 

Patent family: Non-peptide oxytocin receptor agonists. Kassiou M, Jorgensen W, Reekie T, Werry E, Bowen MT

  • (co-inventor), McGregor IS.

  • USA Patent 11491165 (Granted 2022)

  • Australian Patent 2017377653 (Granted 2022)

  • Japanese Patent 7089649 (Granted 2022)

  • Russian Federation Patent Application 2019120162 (Published 2021)

  • Brazilian Patent Application BR112019012049 (Published 2019)

  • Chinese Patent Application 201780085825.X (Published 2019)

  • Indian Patent Application 201917026397 (Published 2019)

  • Israeli Patent Application 267276 (Published 2019)

  • Mexican Patent 398242 (Granted 2022)

  • New Zealand Patent Application 754890 (Published 2019)

  • Republic of Korean Patent Application 10-2019-7019977 (Published 2019)

  • South African Patent Application 2019/04290 (Published 2019)

  • Canadian Patent Application 3046809 (Published 2018)

  • European Patent Convention Patent Application 17880082 (Published 2019)

  • Hong Kong Patent Application 62020004269.0 (Published 2018)

 

Patent family: Methods for management of weight. Bowen MT (co-lead inventor), McGregor IS, Baracz S, Cornish J.

  • USA Patent Application 17/295638 (Published 2022)

  • Australian Patent Application 2019383052 (Published 2020)

​

Patent family: Treatment of opioid withdrawal. Bowen MT (lead inventor), McGregor IS.

  • USA Patent Application 20220288060 (Published 2022)

  • European Patent Convention Patent Application 20861856.1 (Published 2022)

  • New Zealand Patent Application 785640 (Published 2022)

  • Republic of Korea Patent Application 10-2022-7011111 (Published 2022)

  • Chinese Patent Application 202080062769.X (Published 2022)

  • Brazil Patent Application BR112022003889 (Published 2022)

  • Israeli Patent Application 291065 (Published 2022)

  • Australian Patent Application 2020343726 (Published 2021)

  • Canadian Patent Application 3150103 (Published 2021)

  • Japanese Patent Application 2022547178 (Published 2022)

 

Patent family: Methods for treating aggression. Bowen MT (lead inventor)

  • Patent Cooperation Treaty (PCT) Application PCT/AU2022/050244 (Published 2022).

 

Patent family: Therapy and Prevention of Problem Drinking. Bowen MT (co-lead inventor), McGregor IS, Carson DS, Guastella A

  • USA Patent 09119805 (Granted 2015)

  • Australian Patent 2010302945 (Granted 2015)

  • European Patent Convention Patent EP2482835 (Granted 2014).

  • German Patent DE2482835 (Granted 2014)

  • Irish Patent IE2482835 (Granted 2014)

  • Italian Patent IT2482835 (Granted 2014)

  • Spanish Patent ES2482835 (Granted 2014)

  • Swedish Patent SE2482835 (Granted 2014)

  • UK Patent GB2482835 (Granted 2014)

Other Publications

  • World Economic Forum Young Scientists Community (2018). Code of Ethics for Researchers. World Economic Forum, Geneva, Switzerland.

  • Bowen MT. (2017). As scientists, we must fight fake news with truth. World Economic Forum Agenda.

  • Bowen MT. (2017). The Selfish Gene: A book that helped shape my thinking. Sydney University Alumni Magazine

  • Bowen MT, McGregor IS (2015). Could research into oxytocin and alcohol lead to a ‘sobriety pill’? The Conversation. (At publication was the 7th most read The Conversation article of all time from University of Sydney with ~100,000 reads)

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